Journal of Medicine and Applied Sciences 2022-05-23T21:27:56+03:00 Journal of Medicine and Applied Sciences Open Journal Systems <p><strong><em>Journal of Medicine and Applied Sciences</em></strong> is the scientific, peer reviewed, open access publication. The journal is published three times in a year; on April, August, December and its publication language is <strong>Turkish</strong> and <strong>English</strong>.</p> <p>The aim of the journal is to publish high level clinical and experimental studies conducted in all fields of medicine. Case reports, review articles, technical notes and letters to the editor are also published.</p> <p>The target population of the journal includes specialists in all fields of medicine, academicians and relevant health care professionals.</p> <p><strong>No fee</strong> is requested from the authors during the evaluation, publication and publishing of the articles sent to our journal. Articles submitted for publication are subject to double-sided blind review by at least two referees.</p> <p>All manuscripts must be submitted via the online submission system, which is available at The journal guidelines, technical information, and the required forms are available on the journal’s web page.</p> Usage and Importance of Nanoparticle in Radiotherapy 2022-03-12T22:20:19+03:00 Ayşegül Ünal Karabey Mehmet Sinan Karabey Özcan Gündoğdu Maksut Görkem Aksu <p>One of the treatment methods of cancer disease is radiotherapy like surgery and chemotherapy. The aim in radiotherapy is to protect the surrounding healthy tissues from the harmful effects of radiation as much as possible while giving a high dose to the target organ. For this reason, tolerance doses of each organ should be followed and these doses should not be exceeded during the treatment phase. Some types of cancer do not respond to radiation, such cells are called radiation resistant cells. It is important for the success of the treatment to be able to give the dose that can cause radiation damage to the cell. The size of the dose given is important both in terms of not exceeding the tolerance dose of healthy adjacent tissues and in terms of the possibility of secondary cancer. Alternative methods have been sought to increase the effectiveness of the radiation dose given in the treatment. Recent developments in nanotechnology and its applications in the field of radiotherapy are exciting. The nanoparticle makes it possible to treat resistant tumors with its dose sensitivity in the diseased area and at the same time its dose-increasing effect.The purpose of this short review is to give information about some nanoparticle types and their applicability in radiotherapy. Some studies on nanoparticles such as gold, platinum and titanium were compiled and their applications were discussed.</p> 2022-04-30T00:00:00+03:00 Copyright (c) 2022 Journal of Medicine and Applied Sciences Automatic Segmentation of Cerebral Infarct Tissue by Using Computed Tomography Perfusion Maps 2022-02-10T10:58:10+03:00 Emin Emrah Ozsavas Tolga Inal Gokce Kaan Atac Ziya Telatar <p>Computed tomography (CT) perfusion maps are dependent to conditions like patient age, blood pressure, vessel structure and parameters like arterial input choice. Thresholds for stroke infarct and penumbra are well established in literature but they may sometimes lead to misdiagnosis. The aim of the study was to develop a full automatic reliable segmentation algorithm for infarct core by making use of cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT) perfusion maps. We applied the presented method first to digital phantom data. After optimization of the algorithm in phantom data, final algorithm was tried on 21 real patient data retrospectively. The results from pathology-mimicked phantom data were compared with magnetic resonance (MR) diffusion weighted images of the mimicked patient images. The results showed that infarct segmentations were consistent with real pathology information. We compared our results with a commercial neuro perfusion software results on identical patient group. The results showed that infarct segmentations were consistent with priori pathology information and commercial software results with including greater true positive (TP) and less false positives (FP) rates.</p> 2022-04-30T00:00:00+03:00 Copyright (c) 2022 Journal of Medicine and Applied Sciences Are Computed Tomography HU Density Values Useful in Differentiating Embolism and Lymph Node at Hilar Level? 2022-05-23T12:48:05+03:00 Mesut ÖZGÖKÇE İlyas DÜNDAR Fatma DURMAZ Saim TÜRKOĞLU Ensar TURKO Cemil GÖYA Veysel Atilla Ayyıldız <p>Pulmonary embolism (PE) is a vascular disease that causes occlusion and narrowing of the pulmonary arteries in the acute or chronic process, has high morbidity and mortality, is still the most frequently diagnosed in emergency outpatient clinics and causes sudden death. Computed Tomography as a diagnosis is the most frequently used radiological examination in clinical practice. A total of 58 patients who had clinical complaints of chest pain and dyspnea and underwent thoracic CT angiography in the emergency outpatient clinic were included in the study. In our study on 58 patients, we looked at HU density values in the differentiation of lymph nodes, which are frequently confused with PE in the lung hilum. The mean HU densities of the patients with pulmonary embolism were 58.8±5.9 (52-75 HU), and the mean HU densities of the lymph node patients were 66.8±10 (44-87HU). The mean lymph node and thrombus density values from 58 embolism patients were measured as approximately 67 HU and 59 HU, respectively. Although lymph node HU values were higher than embolism in the vessel wall, no statistically significant difference could be obtained (p&gt;0.005). The reason for this may be the age of the thrombus and the abundance of tissues of different densities around the measurement area. For this, a larger number of patients should be examined and thrombus densities of large lymph nodes and acute-chronic stages can be examined separately.</p> 2022-04-30T00:00:00+03:00 Copyright (c) 2022 Journal of Medicine and Applied Sciences The evaluation of self-pharmacy workers’ information, attitudes and behaviors about the antibiotic usage in Van, Turkey 2022-05-23T21:27:56+03:00 Emine Uçar Mehmet Parlak Yasemin Bayram Hüseyin Güdücüoğlu Şevin İrden <p>Inappropriate use of drugs is a serious problem in the world. Correct antibiotic use is an important factor for treatment of infectious diseases. The aim of this study was to determine Behavior and point of view of pharmacy employees to sale of antibiotics without a prescription. The study population comprised pharmacy employees (pharmacists and others) in Van between August and November 2016. A face to face questionnaire was applied to pharmacy employees in cross-sectional study. The first part of the questionnaire consisted 6 questions for sociodemographic characteristics and the second part consisted 17 questions to evaluate behavior and point of view. There are a hundred pharmacies in Van. A total of 75 pharmacies agreed to participate the questionnaire. A total of 159 employes answered the questionnaire, 54 were pharmacists and 105 were other employes. There were no weeks in which asked for antibiotics without a prescription from pharmacies. Most of the employes reported that parents have started antibiotics without prescription for their children at a rate of 10-60 %. The most common complaints/illnesses that had been requested non-prescription antibiotic were upper respiratory tract infection and tooth abscess. The most commonly non-prescribed drugs were painkillers, antibiotics and vitamins, respectively. Improper use of antibiotics by our people is still high. There are many reasons for inappropriate antibiotic use. Pharmacies are an important step in order to prevent wrong and inappropriate use of antibiotic.</p> 2022-04-30T00:00:00+03:00 Copyright (c) 2022 Journal of Medicine and Applied Sciences